Antimicrobial Agents and Chemotherapy
Ethionamide versus ethambutol-containing first-line regimens for TB meningitis
By Xueyi Chen, Carlos E. Ruiz-Gonzalez, Yuderleys Masias-Leon and 4 others.
Abstract
ABSTRACT Ethionamide has emerged as an alternative to ethambutol for the treatment of tuberculous meningitis (TB meningitis). Here, we show that ethionamide- and ethambutol-containing first-line TB regimens achieved similar bactericidal activities in brain tissues and reduction in neuroinflammation in a mouse model of TB meningitis. However, ethionamide, but not ethambutol, achieves brain concentrations above the minimum inhibitory concentration for Mycobacterium tuberculosis.
Keywords
- tuberculosis
- tuberculous meningitis
- chemotherapy
- ethambutol
- ethionamide
Source
Published in Antimicrobial Agents and Chemotherapy. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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