Bisphenol A aggravates colitis-associated intestinal epithelial injury: Mitochondrial dysfunction and CASP1-associated inflammatory signaling

Objective

Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation and epithelial barrier dysfunction. Environmental contaminants may aggravate epithelial injury, but the underlying mechanisms remain unclear. We investigated how bisphenol A (BPA) affects epithelial mitochondrial function and whether CASP1-associated signaling contributes to injury under IBD-relevant inflammatory conditions.