What distinguishes a prerenal cause of acute kidney injury?

Its initiating problem is reduced blood perfusion to the kidneys rather than direct tissue damage or blocked urine outflow.

Postrenal kidney injury mechanism

The initiating problem is obstruction of urine outflow downstream of renal filtration, such as a blocked collecting or urinary passage.

Intrinsic kidney tissue injury

The initiating insult directly damages kidney tissue, such as tubular epithelial injury, rather than being solely a perfusion deficit or an outflow obstruction.

Reduced renal creatinine excretion

If the kidneys filter and excrete creatinine less effectively, it accumulates in blood. This explains the direction of change without making a diagnosis from one isolated result.

In which direction does glomerular filtration move fluid?

Water and sufficiently small solutes move from glomerular capillary blood across the filtration barrier into Bowman's capsular space.

Renal Foundations — Flashcards — Medische flashcarddecks

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