Programmed apoptotic death

Apoptosis is a regulated process in which a cell activates machinery for its own orderly removal, typically involving caspases, contained fragmentation, and phagocytic clearance.

Apoptotic clearance Conventional necrotic injury

Key distinction · Contents packaged into apoptotic bodies for phagocytic clearance, usually limiting inflammation · Loss of cell membrane integrity releases contents and commonly provokes inflammation

Apoptotic bodies are membrane-enclosed fragments of an apoptotic cell. They contain parts of the dying cell and can be removed by phagocytes.

Proteases that cleave protein substrates during apoptosis are called {{c1::caspases}}.

What role does cytochrome c release have in the introductory intrinsic apoptotic pathway?

Release of mitochondrial cytochrome c into cytoplasm helps form the apoptosome and activate an initiator-caspase pathway.

Principles of Pathology — Flashcards — Medische flashcarddecks

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