Frontiers in microbiology
4-Hydroxycoumarin inhibits biofilm formation and enhances antibiotic efficacy against Escherichia coli O157:H7
Door Zhang H, Xu J, Zhou Y en 5 anderen.
Inhoud in het Engels
Abstract
Background
Conventional bactericidal antibiotics often fail to eradicate Escherichia coli O157:H7 (E. coli O157) infections due to biofilm-mediated antimicrobial tolerance, and monotherapy can inadvertently drive resistance selection. This study aimed to identify compounds capable of modulating LuxS/AI-2-related phenotypes and to evaluate their potential to disrupt biofilms and enhance antibiotic efficacy against E. coli O157.