Head and neck pathology
SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis
Door Tahvanainen O, Lagerstam H, Kalfert D en 1 anderen.
Inhoud in het Engels
Abstract
Purpose
Primary salivary gland tumors form a heterogeneous group with diagnostic challenges. Sex-determining region Y-related homeobox 10 (SOX10) is a transcription factor studied in primary salivary gland tumors for over a decade. To date, no systematic review or meta-analysis has been conducted on its expression in salivary gland tumors.
Methods
A PubMed literature search identified all studies in which SOX10 was evaluated by immunohistochemistry in primary salivary gland tumors. Information on SOX10 positivity, staining pattern, percentage of positive cells, and information on the antibody source and clone were tabulated in Microsoft Excel. The meta-analysis was performed with OpenMeta Analyst. The meta-analysis adheres to PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines.