Tumor-on-chip and cancer microphysiological platforms: knowledge structure, thematic evolution, and the emergence of organoid-integrated models, 2010-2025

Background

Cancer microphysiological systems (MPS), including tumor-on-chip platforms, combine engineered microenvironments, controlled fluid transport, and tumor-relevant biological models for cancer modeling, drug testing, and translational research. Organoid-integrated chips represent one developing component within this broader field, but the publication growth, knowledge structure, and changing research priorities of cancer MPS and tumor-on-chip research have not been systematically mapped across major bibliographic databases.