A qualitative evidence synthesis on perinatal screening for sickle cell disease in high-burden countries

Background

Sickle cell disease (SCD) screening can improve lives and reduce mortality through prevention and targeted treatment, but screening programmes are not universally available in the settings which could most benefit from them. We aimed to understand the implementation considerations for prenatal and newborn SCD screening programmes in countries with a high livebirth prevalence of SCD using the socioecological model of health.