PloS one
Spatial organization of HPV-associated immune programs across tissue compartments in oropharyngeal cancer
Door Wakisaka N, Moriyama-Kita M, Kondo S en 4 anderen.
Inhoud in het Engels
Abstract
Background
Human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) is characterized by a distinct immune microenvironment; however, the biological significance of immune-related transcriptional programs may vary according to their spatial localization. We investigated the spatial organization of HPV-associated transcriptional programs across anatomically distinct tissue compartments in OPC.