Evidence-based pharmacotherapy for anxiety disorders comorbid with PTSD: A systematic review

Objective

To evaluate the efficacy, safety, and tolerability of pharmacological interventions for anxiety outcomes in adults with post-traumatic stress disorder (PTSD), including confirmed comorbid anxiety disorders and clinically significant anxiety symptoms. Material and methods: PubMed/MEDLINE, Scopus, Web of Science, PsycINFO, and Cochrane CENTRAL were searched for randomized controlled trials and prospective cohort studies published from 2000 to 2025. Risk of bias was assessed with Cochrane tools, and certainty of evidence with GRADE.