Journal for immunotherapy of cancer
Propionate promotes CD8+ T-cell infiltration and enhances immunotherapy efficacy in colorectal cancer
Door Pan J, Tong L, Fei R en 8 anderen.
Inhoud in het Engels
Abstract
Background
Short-chain fatty acids (SCFAs) produced by the gut microbiota are increasingly recognized as regulators of host immunity, yet the role of individual SCFAs in shaping the tumor immune microenvironment in colorectal cancer (CRC) remains poorly defined. This study aims to investigate the role of propionate in antitumor immunity and immunotherapy responsiveness in CRC.