Acta dermatovenerologica Alpina, Pannonica, et Adriatica
Efficacy of topical polypeptide gel in accelerating early healing of diabetic ulcers: a randomized controlled trial
Door Octarica SG, Widhiati S, Ellistasari EY en 3 anderen.
Inhoud in het Engels
Abstract
Introduction
Diabetic ulcer (DU) remains a major health problem with high morbidity and treatment cost. Effective, rapid, and affordable treatment is essential for its management. Topical polypeptide gel has regenerative, angiogenic, and anti-inflammatory properties that may accelerate wound healing. However, clinical evidence regarding effectiveness is limited.
Methods
A double-blinded randomized controlled trial was conducted involving 26 subjects with DU, randomly allocated into an intervention group that received 7% topical polypeptide and a control group that received hydrocolloid gel. Wound healing was assessed by measuring ulcer surface area reduction on days 7, 14, and 21 compared to baseline.