Systematic review and meta-analysis of biomarkers of sarcopenia and sarcopenic obesity

Objective

Sarcopenia and sarcopenic obesity (SO) are geriatric syndromes characterized by reduced skeletal muscle mass and impaired muscle strength, whose specific biomarkers and underlying mechanisms remain unclear. This study aimed to conduct a meta-analysis and literature review on the associations between biomarkers and sarcopenia/SO by collecting relevant publications over the past 15 years. We intended to further identify the shared and differential biomarkers of these disorders, thereby revealing their distinct pathophysiological processes and providing a basis for precise diagnosis and targeted intervention.