Pharmaceutics
Airway Transepithelial Transport of IgG Formulated with Excipients: A Case Study on What to Consider Regarding Impact on Epithelial Barrier Integrity, IgG Quality and Matrix Effects During the Analytics
Door Rebecca Rittersberger, Gabriel Koslowski, Iman Shrimo en 1 anderen.
Inhoud in het Engels
Abstract
Background
Surface-active excipients such as polysorbate 20 (PS20), polysorbate 80 (PS80), poloxamer 188 (Px188), and cyclodextrin (CD) are widely used to stabilize IgG formulations, including aerosols. However, their effects on transepithelial IgG transport and the reliability of associated analytical readouts remain poorly understood.