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Journal of Clinical Medicine
Door P. Liberski, Szymon Czajka, Krzysztof Żerdziński en 1 anderen.
Inhoud in het Engels
Prognosis prediction in adult intensive care units (ICUs) guides clinical decision-making, realistic goal-setting with families, and resource allocation, but is challenged by the marked heterogeneity of critically ill patients in multi-speciality wards.
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This narrative review critically analyses commonly used prognostic scoring systems by clinical application timeline.
Admission prognostic models, including the Acute Physiology and Chronic Health Evaluation (APACHE II/III/IV), Simplified Acute Physiology Score (SAPS II/SAPS 3) and Mortality Probability Model (MPM), estimate in-hospital mortality from acute physiological derangement and comorbidity; the Clinical Frailty Scale (CFS) adds prognostic value. During the ICU stay, organ dysfunction is tracked with the Sequential Organ Failure Assessment (SOFA/SOFA-2), designed for repeated reassessment, and the Multiple Organ Dysfunction Score (MODS), while the Therapeutic Intervention Scoring System (TISS-28) quantifies nursing workload. At discharge, the Barthel Index, Glasgow Outcome Scale (GOS) and Cerebral Performance Category (CPC) measure functional independence and neurological outcome. Admission-based mortality models use an initial assessment window and may require local recalibration, and discrimination alone does not establish clinical utility.
Future directions include trajectory-based models, phenotyping, biomarkers, time-limited trials and machine learning. Prognostic estimates should inform multidisciplinary evaluation and shared decision-making, rather than independently determine treatment intensity or withdrawal.
Gepubliceerd in Journal of Clinical Medicine. Het abstract staat hier zoals het is gepubliceerd en blijft het werk van de auteurs; lees het volledige artikel bij de bron.
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