ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis (Adv. Sci. 56/2026)

Melanoma Brain Metastasis T cell activation is central to effective immunotherapy in brain metastases. ICOS-immunoPET specifically targets activated T cells, enabling noninvasive visualization of immune engagement and offering a promising strategy for earlier, functionally informative assessment of immunotherapy response. More details can be found in the Research Article by Israt S. Alam, Michael Lim, Michelle L. James, and co-workers (DOI: 10.1002/advs.76803).