International journal of chronic obstructive pulmonary disease
Effective Connectivity and Clinical Correlates in Chronic Obstructive Pulmonary Disease
Par Han KI, Bae JH, Jo HJ et 5 autres.
Contenu en anglais
Résumé
Background
Cognitive impairment is a substantial comorbidity in chronic obstructive pulmonary disease (COPD); however, the neural mechanisms underlying this association remain poorly understood. This study aimed to assess alterations in effective connectivity (EC) in patients with COPD and investigate their relationships with clinical measures.
Methods
Resting-state functional magnetic resonance imaging (RS-fMRI) was performed in 38 patients with COPD and 30 healthy controls. EC was estimated using vector autoregressive (VAR) modelling combined with Granger causality analysis across 26 prespecified brain regions of interest derived from our previous functional connectivity study of the same cohort. Between-group differences in directed connectivity were assessed using Welch's t-tests. Associations between EC measures showing between-group differences and clinical measures were evaluated using age-adjusted partial Pearson correlations.