Journal of global health
Beyond static frailty: longitudinal trajectories, nonlinear associations, and muscle strength mediation in osteoporosis risk
Par Zhou J, Wang JH, Huang Z et 1 autres.
Contenu en anglais
Résumé
Background
Frailty, a multidimensional indicator of declining physiological reserve, has been consistently linked to adverse health outcomes. However, whether dynamic trajectories of the Frailty Index (FI) predict new-onset osteoporosis remains unclear.
Methods
For this longitudinal cohort study, we retrieved data on adults aged ≥50 years from the Health and Retirement Study, the English Longitudinal Study of Ageing, and the Survey of Health, Ageing and Retirement in Europe. We assessed frailty using the FI and identified longitudinal frailty trajectories, examined associations of baseline FI and frailty trajectories with incident osteoporosis, and explored nonlinear relationships and the potential mediating role of grip strength.