Frontiers in genetics
A pilot genome-wide association study of ischemic heart disease with co-occurring arterial hypertension in a Kazakh cohort
Par Skvortsova L, Yergali K, Zhaxylykova A et 2 autres.
Contenu en anglais
Résumé
Background
Genome-wide association studies (GWAS) of ischemic heart disease (IHD) remain underrepresented in Central Asian populations. We conducted a pilot GWAS of ischemic heart disease with co-occurring arterial hypertension (IHD-HTN) in an ethnic Kazakh cohort to identify candidate loci for future replication.
Methods
This study included 470 Kazakh individuals, comprising of 240 cases and 230 controls genotyped using the Illumina Infinium Global Screening Array-24 v 3.0. Association testing was performed using logistic regression under an additive genetic model adjusted for age, sex, and the first 10 principal components. Post-imputation GWAS was performed using high-quality imputed variants. Secondary analyses included MAGMA and KGWAS prioritization.