Potential involvement of a TLR4-associated CD155/TIGIT pathway in Porphyromonas gingivalis-induced immunosuppressive microenvironment formation in oral squamous cell carcinoma

Objective

Accumulating evidence indicates that oral microbiota dysbiosis and periodontal pathogens contribute to the initiation and progression of oral squamous cell carcinoma (OSCC). However, the molecular mechanisms underlying the interaction between Porphyromonas gingivalis and the tumor immune microenvironment remain incompletely understood. This study aimed to investigate the potential role of a TLR4-associated ERK/CD155/TIGIT signaling pathway in P. gingivalis-mediated immunosuppressive microenvironment formation during OSCC progression.