Drug metabolism and bioanalysis
Metabolomics Methods for Detecting Acetaminophen Poisoning: A Systematic Review
Par Murugesan T et Velmurugan H.
Contenu en anglais
Résumé
Introduction
Detecting toxicity patterns in metabolic changes is a key indicator of potential threats. Metabolomics may provide an alternative way to find biomarkers for drug overdose and toxicity. In an acetaminophen overdose, glutathione scavenging causes mitochondrial malfunction and hepatocyte death. Metabolomics methods have enabled the discovery of novel mechanisms of liver injury in acetaminophen (APAP) overdose.
Methods
We conducted a peer-reviewed scientific review to assess the studies on the application of metabolomics in APAP poisoning. We searched PubMed and Scopus databases until February 28, 2025, for relevant original articles. We also looked into the clinicaltrials.gov website and the Indian clinical trial registry.