Topics in spinal cord injury rehabilitation
Feasibility of Tidal Volume Strategies in Subacute Cervical Spinal Cord Injury: A Pilot Randomized Trial
Par Korupolu R, Stampas A, Lohiya S et 8 autres.
Contenu en anglais
Résumé
Objectives
To assess feasibility of comparing moderate-low (8-10 mL/kg predicted body weight [PBW]) tidal volume (mLVT) versus moderate-high (14-16 mL/kg PBW) tidal volume (mHVT) strategies, and to generate exploratory data on respiratory outcomes and systemic inflammation in individuals with subacute cervical spinal cord injury (SCI) requiring mechanical ventilation (MV).
Methods
In a randomized comparative effectiveness pilot trial at 2 inpatient rehabilitation hospitals, adults (≥18 years) with traumatic cervical SCI on MV were randomized to mLVT or mHVT. The primary outcome was feasibility (recruitment, adherence, retention). Secondary outcomes included pneumonia, other pulmonary complications, ventilator-free days (VFDs), and weaning success at discharge. Exploratory outcomes were changes in inflammatory markers (IL-6, IL-8, TNF-α, IL-1β). Bayesian regression models estimated relative risks (RR) and posterior probabilities.