Inflammatory Aging-Driven Immune Axis Imbalance and the Mechanisms of Chronicity in Elderly Atopic Dermatitis: A Systematic Review and Meta-Analysis

Background

Elderly atopic dermatitis (elderly AD) is increasingly recognized as a chronic inflammatory skin disorder with immunopathological features that may differ from those in younger populations. Age-related chronic low-grade inflammation (inflammaging) may contribute to this phenotype, but its relationship with immune dysfunction and disease chronicity remains incompletely understood.