Food & function
Comparative anti-obesity efficacy of high-interest natural products in preclinical models: a bibliometric and network meta-analysis
Par Chen YX, Yang QW, Zhang L et 7 autres.
Contenu en anglais
Résumé
Objective
to identify research hotspots in natural products for obesity and compare their relative efficacy in preclinical models.
Methods
bibliometric analysis was performed using CiteSpace and Bibliometrix on publications from the Web of Science Core Collection and PubMed up to January 31, 2026, to identify the five most frequently studied natural products. A systematic review and network meta-analysis (NMA) of animal studies evaluating monotherapy with these five natural products were conducted. The primary outcomes were body weight and epididymal white adipose tissue (eWAT), while secondary outcomes included fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Random-effects consistency models were used for data synthesis. Treatment rankings were estimated using the Surface Under the Cumulative Ranking (SUCRA) curve. Meta-regression and subgroup analyses were performed to explore heterogeneity.