Early Oral P2Y12 Inhibitor Loading in Patients with ST-segment Eleva-tion Myocardial Infarction Undergoing Primary PCI: A Systematic Re-view and Meta-analysis

Introduction

Whether oral P2Y12 inhibitor loading should be given before hospital arrival or deferred until angiography remains uncertain in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). We compared the efficacy and safety of early loading with later in-hospital, catheterization-laboratory, downstream, or no pretreatment.