Acta Neurologica Indonesia
Safety and Clinical Outcomes of Intravenous-to-Oral Antibiotic Switch Therapy in Patients with Brain Abscess: A Systematic Review
Par Sucipto, Thania Vinsalia et Katheryn Etania.
Contenu en anglais
Résumé
Background
Brain abscess requires prolonged intravenous (IV) antibiotics, but early transition-to-oral-switch (IVOS) therapy may reduce hospital stay and healthcare burden. Evidence on safety, efficacy, and timing remains limited.
Methods
A systematic search of PubMed, Cochrane Central, ScienceDirect, and Taylor & Francis identified 67 studies; four met inclusion criteria, including 542 patients. Data on demographics, IV and oral antibiotic regimens, therapy duration, clinical outcomes, and adverse events were extracted.