Investigation of the Effectiveness of Continuous Renal Replacement Therapy (Crrt) on Blood Urea Nitrogen and Serum Creatinine Values in Dogs and Cats with Renal Failure

This study aimed to evaluate the effectiveness of continuous renal replacement therapy (CRRT) on blood urea nitrogen (BUN) and serum creatinine (CREA) levels in cats and dogs with renal failure where conventional treatment methods were insufficient. The distribution characteristics of the data were examined using the Shapiro-Wilk test, and it was determined that they did not show a normal distribution. Therefore, non-parametric statistical methods were applied. Comparisons between treatment groups (CRRT and medical treatment) were performed using the Kruskal-Wallis test, and pairwise post hoc comparisons were carried out using the Dunn test and Bonferroni correction for parameters showing significant differences. Changes over time in animals receiving CRRT treatment were examined using the Friedman test, and median values and time-dependent change curves were evaluated. Furthermore, the biochemical recovery time was analyzed using a Kaplan-Meier-like method. In cats, CRRT treatment resulted in a significant decrease in BUN, creatinine, and inorganic phosphorus levels; changes were more limited in the medical treatment group. In dogs, a decrease in parameters was also observed after CRRT, but some changes were not statistically significant. Kaplan-Meier analysis showed that biochemical recovery in cats occurred in approximately six hours for BUN and IP, and approximately five hours for creatinine. In dogs, creatinine recovered rapidly (approximately one hour), while BUN and IP returned to normal within six and four hours, respectively. CRRT offers a significant therapeutic advantage over conventional medical treatment in cases of severe renal failure, particularly in cats, by enabling faster and more significant recovery of important renal biomarkers.