Parenteral Human Placental Extract and…

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Results

Clinical studies were concentrated in South Korea, Japan, India, and China. In older adults, eight weeks of subcutaneous HPE significantly improved the between-group change in physical function compared with placebo (P=0.036). In a randomized trial involving 108 women with menopausal symptoms, the Kupperman Menopausal Index decreased by 12.30±10.44 points with HPE versus 7.15±9.11 with placebo (P=0.012). Another trial involving 84 women demonstrated improvement in menopausal symptoms (P=0.033) and increased estradiol concentrations (P=0.031) compared with placebo. A placebo-controlled trial involving 78 participants with chronic fatigue reported significant improvements in fatigue measures, particularly in the chronic fatigue syndrome subgroup. In alcoholic or non-alcoholic steatohepatitis, a randomized comparative trial found that a reduction in alanine aminotransferase of at least 20% occurred in 62.9% of HPE-treated participants versus 48.8% of comparator-treated participants in the per-protocol population (P=0.0772), without demonstrating superiority. A smaller NASH pilot study found significant reductions in aminotransferases at week 8, but not at weeks 12 or 24, and no statistically significant improvement in the NAFLD Activity Score (P=0.078). In shoulder impingement syndrome, three weekly ultrasound-guided injections of 4 mL HPH significantly improved pain, disability, and health-related quality of life compared with placebo (all P<0.001). In OSMF, intralesional placental extract improved mouth opening and burning symptoms, although combination therapies or active comparators produced greater improvements in some studies. A randomized Chinese study involving 156 adults with sensitive skin demonstrated improvement in facial hemoglobin content and global aesthetic assessment after three intradermal mesotherapy sessions. However, a placebo-controlled pharmacopuncture trial did not demonstrate significant superiority for its primary menopausal hot-flash endpoint. No clinical study demonstrated increased human lifespan or reduced mortality.

Parenteral Human Placental Extract and Hydrolysate Therapy: Clinical Applications, Dosing Regimens, Healthy Aging, And Aesthetic Uses — A Scoping Review

Résumé

Background

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Objective

Methods

Results

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