Zenodo
Immunomodulatory drugs in ophthalmology: A comprehensive review of indications, contraindications and emerging evidence
Par Dr. Vandana Jain.
Contenu en anglais
Résumé
Background
Ocular inflammatory and autoimmune diseases represent a heterogeneous group of conditions that, when inadequately controlled, lead to irreversible structural damage and visual impairment. Conventional corticosteroids, while effective for acute suppression, are associated with a well-documented constellation of sight-threatening and systemic adverse effects with prolonged use, necessitating the integration of steroid-sparing immunomodulatory therapy (IMT).
Methods
A comprehensive narrative review of peer-reviewed literature published between 2015 and 2025 was conducted using PubMed, MEDLINE, and Cochrane databases, encompassing randomized controlled trials, systematic reviews, meta-analyses, and landmark observational cohort studies.