Thyroid Research and Practice
Maternal antenatal endocrinopathy and infant congenital heart disease: Stratified analysis from a case-control study
Par Prasad Manne, Vithiavathi Sivasubramanian et Rakesh Sehgal.
Contenu en anglais
Résumé
Introduction
Diabetes mellitus is a recognized maternal risk factor for congenital heart disease anomalies, but the role of hypothyroidism is often under-emphasized in screening protocols. This subgroup analysis from case-control study evaluated whether maternal diabetes and hypothyroidism carry comparable risk for congenital heart disease.
Methods
From a hospital-based case-control study of risk factors for congenital heart disease, we analysed 280 infants with Echocardiography confirmed congenital heart disease diagnosed before 1 year of age and 280 hospital-matched controls. Maternal endocrinopathy was defined as: 1) Diabetes: pre-gestational type 1 or type 2 diabetes, diabetes diagnosed during pregnancy, gestational diabetes mellitus managed by diet alone, or diabetes requiring oral medication or insulin; 2) Hypothyroidism: diagnosed before conception or during pregnancy. Data were extracted from antenatal records and maternal interview. Odds ratios with 95% CI were calculated using Fisher’s exact test.