Metabolic dysfunction is associated with non-eosinophilic asthma phenotype: a retrospective cross-sectional study

Aim

Asthma is a heterogeneous airway disease comprising distinct inflammatory phenotypes with variable clinical characteristics and treatment responses. Increasing evidence suggests that obesity-related metabolic dysfunction contributes to asthma pathogenesis; however, its relationship with eosinophilic asthma remains incompletely understood. This study aimed to evaluate metabolic dysfunction in patients with asthma and investigate its association with the eosinophilic phenotype using multiple insulin resistance-related metabolic indices.