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Journal of HerbMed Pharmacology
Par Tchang Alkali Wangbara, Kidjama Ngo Ngimout, Joseph Ngaibi et 5 autres.
Contenu en anglais
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Temporal lobe epilepsy (TLE) is characterized by an imbalance between excitatory and inhibitory systems associated with neuroinflammation. These mechanisms contribute to therapeutic resistance and disease progression. Crassocephalum bauchiense (Hutch.) Milne-Redh. (Asteraceae) has traditionally been used in the management of convulsions and epilepsy. This study aimed to investigate the antiepileptic potential of C. bauchiense in a kainate‑induced mouse model of TLE.
In this experimental study, a single intraperitoneal injection of kainate (15 mg/kg) was used to induce status epilepticus (SE). Over the following two weeks, mice received daily oral treatment with distilled water, sodium valproate (300 mg/kg), or C. bauchiense extract (280, 140, 70, and 28 mg/kg). Seizure susceptibility was tested with pentylenetetrazol (15 mg/kg, i.p.), and hippocampal gamma‑aminobutyric acid (GABA), GABA aminotransferase (GABA‑T), and cytokines were measured.
The extract increased (P < 0.001) seizure latency by 58.9-175% (doses 70-280 mg/kg), reduced duration and frequency of recurrent seizures, and at 140-280 mg/kg showed effects comparable to sodium valproate. GABA rose by 49.32%, while GABA‑T decreased by 57.64% at the highest dose, restoring inhibitory neurotransmission (P < 0.001). Interleukin 1 beta (IL‑1β), interleukin 6 (IL‑6), interferon gamma (IFN‑γ) and tumor necrosis factor alpha (TNF‑α) were suppressed in a dose-dependent fashion, with the strongest effects (P < 0.001) observed at the higher doses. Moreover, the dysregulated level of interleukin‑10 (IL‑10) was corrected by the treatment.
The antiepileptic effects were associated with restoration of GABAergic signaling and attenuation of neuroinflammatory markers. These results support the future development of C. bauchiense as a source of bioactive compounds with antiepileptic potential.
Publié dans Journal of HerbMed Pharmacology. Le résumé est reproduit tel qu’il a été publié et reste l’œuvre de ses auteurs ; lisez l’article complet à la source.
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