Journal of HerbMed Pharmacology
A systematic review of fisetin in oral premalignant and malignant disorders: Molecular mechanisms and therapeutic potential
Par Mehran Taheri Khafri, Zahra Khiali et Kosar Farhadi Babadi.
Contenu en anglais
Résumé
Introduction
Oral cavity neoplasms pose a public health concern worldwide. We aimed to systematically review the current molecular mechanisms and preclinical efficacy of fisetin (FIS) in oral premalignant and malignant disorders.
Methods
A systematic review was conducted following the PRISMA guidelines, and keyword searches were performed in electronic databases such as PubMed, Scopus, Cochrane Library, and Web of Science. After screening the publications based on the inclusion and exclusion criteria, the desired data were extracted from the articles and recorded. Also, the risk of bias assessment was conducted using the Quality Assessment Tool for In Vitro Studies (QUIN) and the SYRCLE Risk of Bias tool.