Efficacy and Safety of Lythrum salicaria Extract on Body Fat Reduction in Adults with a BMI of 23–30 kg/m2: A Randomized, Double-Blind, Placebo-Controlled Trial

Background/Objectives: Plant-derived ingredients have attracted interest as adjuncts for reducing body fat, but clinical evidence for Lythrum salicaria extract alone remains limited. We evaluated its effects on body fat and its safety in adults with a body mass index (BMI) of 23–30 kg/m2.

Methods

Ninety adults aged 19–75 years participated in a single-center, randomized, double-blind, placebo-controlled trial. Participants received either 500 mg/day of L. salicaria extract powder (corresponding to approximately 400 mg/day of plant-derived extract solids) or placebo for 12 weeks. The primary endpoint was the change in body fat mass from baseline to day 84, assessed by dual-energy X-ray absorptiometry (DXA). Efficacy was evaluated primarily in the per-protocol (PP) population, with supporting intention-to-treat (ITT) analyses. Anthropometric measures, other DXA outcomes, and blood markers were assessed as secondary endpoints.