Nutrients
Maternal Obesity Induces DNA Methylation Changes in the Kidneys and Blood of Rodent Offspring at Adulthood
Par Benjamin P. Larkin, Long The Nguyen, Naveen Kumar Parthiban et 6 autres.
Contenu en anglais
Résumé
Aim
To identify differentially methylated genes in offspring of obese versus lean mothers using a mouse model of maternal obesity.
Background
Adverse conditions during fetal development predispose offspring to adult diseases, supporting the theory of fetal programming. DNA methylation is suggested as a mechanism by which maternal obesity induces fetal programming. As maternal obesity predisposes offspring to chronic kidney disease (CKD), we aimed to investigate the role of DNA methylation in maternal obesity related to CKD in the offspring.