Aller au contenu

Se connecter Commencer

Créer votre compte gratuit

Chargement de votre page…

We care for the people who care.

Pas de publicité. Pas de revente de vos données. Aucun traceur tiers.

Apps

Prognia
Ward
Suture
Osler

Bibliothèque

Recommandations
Médicaments
Articles
Calculateurs
Explorer les decks
Établissements
Laboratoires pharmaceutiques
Blog

Prognia

À propos
Tarifs
Contact

Nous soutenir

Founders Wall

Pour les organisations

Hôpitaux
Universités et facultés de médecine
Laboratoires pharmaceutiques

© 2026 Prognia · Amsterdam, Pays-BasConfidentialité ConditionsExchangeRate-API

Muscles

Is the End-Exercise Potentiated-Twitch Decrement a Regulated Variable? A Mechanism-Oriented Review of Muscle Fatigue During High-Intensity Aerobic Exercise

9 octobre 2026Recherche originale1 min de lecture

Par Arnulfo Ramos‐Jiménez, Mariazel Rubio-Valles, Marina Trejo-Trejo et 5 autres.

Contenu en anglais

Lire l’article original

Sur cette page

Résumé
Mots-clés
Auteurs
Source

Résumé

Background

Fatigue in high-intensity exercise is often attributed to a defended ceiling of peripheral fatigue; evidence is mixed.

Objectives

We aimed to assess whether the end-exercise potentiated-twitch decrement behaves as a regulated variable across candidate mechanisms.

Methods

Approfondissez un sujet pendant vos révisions.

Ward réunit ces articles dans la même app que vos cartes et vos questions. Un seul compte gratuit pour Ward, Suture, Osler et Prognia.

Découvrir Ward

PubMed/MEDLINE, Scopus, and Web of Science were searched to 12 August 2026. Evidence came from controlled studies in adults, with permeabilized-fiber, rodent, and isolated-actomyosin experiments only where human measurement is impossible.

Results

Nine mechanisms met the criteria. Inorganic phosphate and hydrogen ions impair the cross-bridge cycle; reduced sarcolemmal excitability (K+) and reduced sarcoplasmic reticulum Ca2+ release reverse over minutes and days, respectively. Only the cross-bridge effects are driven by metabolites (protons, ATP, lactate) that are agonists of group III/IV afferents; the afferents do not sense contractile impairment itself. Oxygen delivery, respiratory-muscle work, substrate availability, and perceptual load altered fatigue rate more than the end-exercise value, which varied with duration, prior exercise, muscle mass, and mode.

Conclusions

Evidence fits a threshold in the phosphate–force relationship, though this does not demonstrate a defended limit. The decrement is not constant across tasks; we propose, as a testable hypothesis, that the regulated quantity is the summed afferent and effort signal. Selection was purposive, without formal risk-of-bias appraisal.

Mots-clés

Cardiovascular and exercise physiology
Open access

Auteurs

Arnulfo Ramos‐Jiménez
Mariazel Rubio-Valles
Marina Trejo-Trejo
Cristhian Emmanuel López-Campos
Jaime Guereca Arvizuo
Oliver A. Sollano-Trejo
María Guadalupe DELGADILLO-RAMOS
Marco Antonio Hernández-Lepe

Source

Publié dans Muscles. Le résumé est reproduit tel qu’il a été publié et reste l’œuvre de ses auteurs ; lisez l’article complet à la source.

doi.org/10.3390/muscles5040074

Prognia référence cet article à des fins de documentation et de formation. Il ne constitue pas un avis médical. Lisez toujours l’original et suivez les recommandations en vigueur et les protocoles locaux avant d’agir.

En bref

Revue: Muscles
Type: Recherche originale
Publié: 9 octobre 2026
Spécialité: Cardiologie
Temps de lecture: 1 min
Auteurs: 8
DOI: 10.3390/muscles5040074

À lire aussi : cardiologie

Real-World Cardiovascular Disease Awareness and Educational Interventions: Their Impact on Medical Student Confidence in Recognizing Cardiac ConditionsMedEdPublish · 2026Ajouté aujourd’huiNouveau
Connected but Unequal: Cardiovascular Risk Burden and Digital Health Engagement Among US AdultsPreprints.org · 2026Ajouté aujourd’huiNouveau
Various Subtypes of Endometriosis and Cardiovascular Disease: Emerging Molecular Links and Clinical Implications: A Narrative ReviewPreprints.org · 2026Ajouté aujourd’huiNouveau
Cardiovascular Risk Burden Assessed by China-PAR Score and Its Link to Cognitive Performance in Older Adults: A Cross-Sectional StudyResearch Square · 2026Ajouté aujourd’huiNouveau
Human Plasma Causal Immunome-Phenome Mapping Reveals Cardiovascular Enrichment and Therapeutic Target OpportunitiesResearch Square · 2026Ajouté aujourd’huiNouveau
Cardiac MRI at 3.0T in the presence of implantable cardioverter defibrillators (ICDs)medRxiv · 2026Ajouté aujourd’huiNouveau
Plantar Thermography for Longitudinal Remote Monitoring of Chronic Heart FailuremedRxiv · 2026Ajouté aujourd’huiNouveau
Fully Automated Multi-Chamber Strain Profiling in Consecutive Patients Undergoing Transthoracic Echocardiography: Feasibility, Functional Clustering, and Prognostic ImplicationsmedRxiv · 2026Ajouté aujourd’huiNouveau
Exercise for Older People with Heart Failure and Frailty: Should We Even Try?ESC Heart Failure · 2026Ajouté aujourd’huiNouveau
Left Ventricular Diastolic Intraventricular Pressure Differences and Propagation Velocity with 4D-Flow MRI in Patients with Hypertrophic CardiomyopathymedRxiv · 2026Ajouté aujourd’huiNouveau
Reporting of Pericardial Adverse Events with Immune Checkpoint Inhibitors: A Disproportionality Analysis of the FDA Adverse Event Reporting SystemmedRxiv · 2026Ajouté aujourd’huiNouveau
Comparative prognostic value of simple, formula-derived, and biomarker-based adiposity indices for cardiovascular disease and mortality: a UK Biobank cohort studyBMC Public Health · 2026Ajouté aujourd’huiNouveau

Articles
Cardiologie