Metabolites
Hepato-Immune Crosstalk Underlies Antipsychotic-Associated Metabolic Dysregulation in Schizophrenia: Quercetin as a Therapeutic Candidate for High-Inflammatory Subtypes
Par Yi Yang, Bin Liu, Zhicheng Cao et 10 autres.
Contenu en anglais
Résumé
Background
Patients with schizophrenia (SCZ) receiving antipsychotic treatment frequently develop metabolic complications, yet the mechanisms underlying liver-immune crosstalk remain poorly characterized.
Methods
This study recruited 340 antipsychotic-treated SCZ patients and 340 matched healthy controls, with a 2-year follow-up restricted to the patient cohort. Candidate genes with hepatic metabolic relevance were screened from the independent GSE21138 brain transcriptomic dataset using machine learning. Molecular docking was performed to predict binding interactions of quercetin as a candidate bioactive compound.