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Comparative Metabolic Effects of Glibenclamide in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Par Juan José Valenzuela‐Fuenzalida, Antonia Jaña-Barria, Ana Ferrer-Contreras et 13 autres.
Contenu en anglais
Résumé
Background
Glibenclamide remains widely used for glycemic control in type 2 diabetes mellitus (T2DM), but its comparative metabolic effects across glycemic, lipid, anthropometric, and cardiometabolic outcomes remain uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing glibenclamide with other antidiabetic therapies.
Methods
We restricted eligibility to randomized trials in adults with T2DM. We performed random-effects meta-analyses for continuous outcomes; we assessed statistical heterogeneity using I2, risk of bias using Cochrane RoB 2, and certainty of evidence using GRADE.