Effect of Hyperbaric Oxygen Therapy in Reducing Intestinal Edema After Traumatic Liver Injury with Abdominal Packing: An Experimental Animal Study

Background

Traumatic liver injury in severe trauma and temporary abdominal closure can lead to postoperative intestinal edema and inflammation. Hyperbaric oxygen therapy (HBOT) may mitigate these effects by modulating inflammatory pathways. This study investigated the effects of HBOT on mucosal preservation, with villus height and the villus-to-crypt (V/C) ratio as primary outcomes and mechanistic analyses of the NLRP3/caspase-1 pathway.