Life
Metabolomic Profiling of Gestational Diabetes Mellitus and Its Subtypes Among Chinese Pregnant Women
Par Xialidan Alifu, Yiwen Qiu, Boya Wang et 10 autres.
Contenu en anglais
Résumé
Background
This study aimed to explore first-trimester metabolic profiles associated with gestational diabetes mellitus (GDM) and its glycemic subtypes.
Methods
This nested case–control study included 90 women with GDM, comprising 30 with isolated fasting hyperglycemia (IFH), 30 with isolated post-load hyperglycemia (IPH), and 30 with combined hyperglycemia (CH), together with 30 women with normal glucose tolerance (NGT). Untargeted UHPLC-MS metabolomic profiling was performed on fasting plasma samples collected during the first trimester. Exploratory metabolic features were compared between GDM or its subtypes and NGT, and Spearman correlation analyses were performed to examine associations between candidate metabolic features and maternal fasting blood glucose (FBG), BMI, thyroid-related parameters, parity, education, and gestational weight gain. Exploratory pathway analyses were conducted to characterize potentially related metabolic processes.