Journal of Personalized Medicine
A Two-Phase Translational Framework for Personalized Ozone Therapy: From Baseline Clinical Redox Screening to Individualized Ex Vivo Concentration Selection
Par Ioannis Iliakis, Emmanouil Iliakis et Demitrios H. Vynios.
Contenu en anglais
Résumé
Background
Medical ozone therapy traditionally relies on standardized concentration protocols. However, interindividual variability in baseline oxidative stress and antioxidant capacity suggests that uniform dosing may be biologically suboptimal.
Objective
To evaluate baseline redox heterogeneity in patients with musculoskeletal disorders and investigate whether an ex vivo graded ozone exposure framework using the FRAS5 system can identify personalized optimal redox response.