Preschool Outcome After Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy: Insights from Early Neurodevelopmental Assessment

Background

Therapeutic hypothermia has significantly improved the prognosis of infants with hypoxic–ischemic encephalopathy (HIE), shifting the focus of follow-up toward the identification of early predictors of preschool neurodevelopmental outcome. This study aimed to evaluate the predictive value of early neurological, developmental and neuroradiological assessments in children with HIE treated with therapeutic hypothermia.