Journal of Clinical Medicine
Factors Associated with Major Versus Minor Lower Extremity Amputation in Hospitalized Patients with Diabetes in Saudi Arabia
Par Fathia Ahmed Mersal, Salma M. Alzarawi, Nahed Ahmed Mersal et 3 autres.
Contenu en anglais
Résumé
Background
Major lower extremity amputation (LEA) is a severe complication of diabetes with substantial disability and mortality. Evidence from Saudi Arabia with distinguishing factors linked to major versus minor amputation is limited. We examined demographic, clinical, vascular, and wound-related factors associated with amputation level among hospitalized patients with diabetes who had already undergone LEA.
Methods
We conducted a retrospective comparative observational study of 230 adults with diabetes who underwent non-traumatic LEA at Al Noor Specialist Hospital, Makkah. Because the cohort comprised exclusively patients who had already undergone amputation, the analysis was explanatory in purpose and characterized factors associated with the level of amputation (major versus minor) rather than predictors of amputation occurrence in the broader population of patients with diabetic foot disease. Independent associations were examined using multivariable binary logistic regression with Firth’s penalization; adjusted odds ratios (aORs) with 95% confidence intervals were the principal results, and exploratory model diagnostics .