Journal of Clinical Medicine
Kidney Outcomes in Offspring Exposed to Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis
Par Limei Xiong, Yan Zhang, Yuanxi Liao et 3 autres.
Contenu en anglais
Résumé
Background
Hypertensive disorders of pregnancy (HDP) may impair placental function and disrupt foetal nephrogenesis, increasing kidney vulnerability in offspring. However, the magnitude and phenotype-specific pattern of offspring kidney risk remain uncertain. We aimed to systematically assess the association between maternal HDP and offspring kidney outcomes.
Methods
PubMed, EMBASE, Cochrane Library, Wanfang Data, and China National Knowledge Infrastructure were searched from inception to October 2025. Cohort and case–control studies evaluating maternal HDP and offspring kidney outcomes were included. Outcomes were grouped into three final categories, including chronic kidney disease (CKD), acute kidney injury (AKI), and congenital anomalies of the kidney and urinary tract (CAKUT). Two reviewers independently screened studies, extracted data, and assessed risk of bias. Pooled effect estimates were derived from random-effects meta-analysis using the generic inverse variance method, prioritising the adjusted estimates. The protocol was registered with PROSPERO (CRD420251175714).