Impact of Functional Frailty Measured by Short Physical Performance Battery Test on the Effectiveness of SGLT2 Inhibitors in Elderly Patients with Acute Heart Failure:PROFUND-IC Registry

Background/Objectives: Acute heart failure (AHF) is the leading cause of hospitalization among patients over 65 years and is frequently associated with frailty. Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) currently represent the only drug class recommended across the entire ejection fraction spectrum, although evidence regarding their effectiveness according to frailty status remains limited.