Therapeutic Value of Budesonide Nasal Irrigation for Postoperative Maintenance of Chronic Rhinosinusitis: A Real-World Study

Objectives

Budesonide irrigation (BI) has emerged as an effective postoperative topical therapy for chronic rhinosinusitis (CRS), providing improved drug delivery compared with conventional intranasal corticosteroid sprays. However, evidence regarding its role as a maintenance strategy during the critical postoperative period remains limited. This study aimed to evaluate the clinical efficacy of BI compared with saline irrigation (SI) in patients with persistent symptoms following functional endoscopic sinus surgery (FESS) and to determine whether treatment effects differed according to CRS inflammatory endotypes.