Journal of Cardiovascular Development and Disease
Titin Serum Level Is Elevated in Patients with Myocarditis Depending on Their Genetic Background
Par Yu. A. Vakhrushev, Sofia Mayrina, S. E. Andreeva et 6 autres.
Contenu en anglais
Résumé
Background
The molecular basis of myocarditis is often associated with genetic cardiomyopathies and truncating or loss-of-function variants in the titin gene (TTNtv/lof). Here, we hypothesize that titin serum levels increase in patients with myocarditis, and that this can depend on the genetic background of the disease.
Methods
Forty-six patients with myocarditis were included in this study. Genotyping was performed using targeted panel sequencing. Serum titin levels and titin/creatinine ratios were measured in a subgroup of 27 patients.