Cross-Platform External Validation of a Locked 12-Gene Prognostic Panel in Lung Adenocarcinoma Benchmarked Against Pathological Stage

Background/Objectives: A prognostic gene panel is clinically useful only if its risk ranking survives transfer across measurement platforms and adds information to pathological stage. We evaluated the cross-platform transportability of a 12-gene panel selected in TCGA-LUAD and fixed before external scoring, separating panel performance from model choice and benchmarking it against stage.

Methods