Genes
Histology-Stratified Clinical and Prognostic Associations of PDCD-Related Genes in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma
Par Seong-Tae Kim, Yunha Lee, Se-Young Yun et 8 autres.
Contenu en anglais
Résumé
Background
The prognostic relevance of PDCD-related genes in non-small cell lung cancer remains uncertain. We examined PDCD2, PDCD4, PDCD5, PDCD10, and AVEN separately in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC).
Methods
Matched TCGA expression cohorts comprised 492 LUAD and 484 LUSC tumors. Primary Cox models evaluated continuous expression per standard deviation using separate gene-specific models adjusted for age, sex, smoking history, and pathologic stage. Benjamini–Hochberg correction covered ten gene–histology tests. Proportional hazards, multicollinearity, model specification, and the incremental value of PDCD4 were assessed. GSE30219 provided 83 LUAD and 61 LUSC patients for unadjusted and clinically adjusted external analyses. Hallmark enrichment was evaluated using legacy RSEM expression and a STAR TPM sensitivity analysis.