Diseases
Exploratory Comparison of Routine Inflammatory Biomarkers in Nasopharyngeal Carcinoma and Benign Adenoid-Associated Pathology
Par Darius Radu Roman, Carmen Delia Nistor-Cseppento, Dana Carmen Zaha et 5 autres.
Contenu en anglais
Résumé
Background
Nasopharyngeal carcinoma (NPC) may be accompanied by systemic inflammatory changes, but routine inflammatory markers are nonspecific and have not been validated as diagnostic tests for NPC.
Methods
This exploratory retrospective comparison screened 178 adults and included 72 eligible records (36 histopathologically confirmed NPC and 36 histologically confirmed benign adenoid-associated pathology); 106 records were excluded because of incomplete endoscopic or laboratory records (n = 41), hematological malignancy (n = 15), severe hepatic failure (n = 11), or a documented systemic inflammatory condition unrelated to the nasopharyngeal presentation (n = 39). CRP, erythrocyte sedimentation rate (ESR), leukocyte count, selected biochemical variables, and an investigator-derived loco-regional clinical/endoscopic severity score were compared. Prespecified sensitivity analyses included age- and sex-adjusted rank regression, restriction to the overlapping age range (39–52 years), group-stratified correlations, and partial rank correlations adjusted for diagnostic group, age, and sex.